Prof Dr Cyrille Boyer

University of New South Wales, Australia

Topic of Presentation:

Engineering nanostructured materials via 3d printing with fully recyclable resins

Scientia Professor Cyrille Boyer is Associate Dean (Research and Training) for the Faculty of Engineering and an Australian Laureate Fellow at the University of New South Wales, who is specialized in synthesizing functional macromolecules for applications in nanomedicine, advanced materials, and energy storage. He has pioneered photoinduced electron/energy transfer – reversible addition fragmentation chain transfer (PET-RAFT) polymerization (an efficient living radical polymerization which can be activated by light), synthetic bioactive macromolecules (such as antimicrobial polymers), and 3D printing methods for precise control over nano- and macro-structures. He has coauthored over 450 articles, which have generated over 44,500 citations, resulting in H-index of 118 (Google Scholar). Boyer's work has earned him over 30 prestigious awards including the 2016 ACS Macro Letters/Biomacromolecules/Macromolecules Young Investigator Award, 2018 IUPAC-Polymer International Young Researcher award, 2015 Lefevre Award from the Australian Academy of Science, and the 2015 Malcolm McIntosh Prize for Physical Science (one of the Prime Minister Prizes for Science). A Highly Cited Researcher every year since 2018, he has also been named among Australia’s top 250 researchers and recognised as a national leader in polymers and plastics by The Australian newspaper.

ENGINEERING NANOSTRUCTURED MATERIALS VIA 3D PRINTING WITH FULLY RECYCLABLE RESINS

Cyrille Boyer^a,*

^aUniversity of Birmingham

Corresponding Author:cboyer@unsw.edu.au

Abstract

Currently, there are no straightforward methods to 3D print materials with nanoscale control over morphological and functional properties. In this talk, a novel approach for the fabrication of materials with controlled nanoscale morphologies using a rapid and commercially available Digital Light Processing 3D printing technique will be presented. The approach uses a controlled/living radical polymerization technique, more specifically, reversible addition-fragmentation chain-transfer (RAFT) polymerization, to control the topologies of the polymers.^[1-2] In this talk, we report a rapid visible light mediated polymerization process and applied it to a 3D printing system.^[3] Following the optimization of the resin formulation, a variety of 3D printing conditions will be presented to prepare functional materials.^[4] The mechanical properties of these 3D printed materials were investigated under different conditions, showing that the control of the polymer structure can affect the performance of these materials.^[5] Furthermore, the polymer networks were able to be reactivated after the initial 3D printing process, which allowed the post functionalization of the printed materials via secondary photopolymerization processes, enabling to introduce information.^[6] Finally, by controlling the polymer architecture, we were able to precisely control the nanostructure of these 3D printed materials via a polymerization induced microphase separation.^[7] The effect of nanostructure on 3D printed material properties will be discussed as well as their potential applications in drug delivery and energy storage, such as their use as solid polymer electrolytes for supercapacitor application. Finally, we will discuss a new approach for the recovery of resin after 3D printing enabling us to recycle these 3D printed materials.

Keywords: Photopolymerization, PET-RAFT, 3D printing

References

[1] A. Bagheri, C. M. Fellows, C. Boyer, Reversible Deactivation Radical Polymerization: From Polymer Network Synthesis to 3D Printing. Adv. Sci. 2021, 8 (5), 2003701.

[2] Z. Zhang, N. Corrigan, A. Bagheri, J. Jin, C. Boyer A Versatile 3D and 4D Printing System through Photocontrolled RAFT Polymerization. Angew. Chem. Inter. Ed. 2019, 58 (50), 17954-17963.

[3] Z. Zhang, N. Corrigan, C. Boyer A Photoinduced Dual-Wavelength Approach for 3D Printing and Self-Healing of Thermosetting Materials. Angew. Chem. Inter. Ed. 2022 134 (11), e202114111

[4]. X. Shi, J. Zhang, N. Corrigan, C. Boyer, Controlling mechanical properties of 3D printed polymer composites through photoinduced reversible addition–fragmentation chain transfer (RAFT) polymerization. Polym. Chem. 2022, 13 (1), 44-57.

[5]. K. Lee, N. Corrigan,C. Boyer, Rapid High-Resolution 3D Printing and Surface Functionalization via Type I Photoinitiated RAFT Polymerization. Angew. Chem. Inter. Ed. 2021, 60 (16), 8839-8850; V. Bobrin, K. Lee, J. Zhang, N. Corrigan, C. Boyer, Nanostructure Control in 3D Printed Materials. Adv. Mater. 2022, 34 (4), 2107643

Prof Dr Elizabeth Gillies

Western University, Canada

Topic of Presentation:

Self-immolative polymers: chemistry and applications of stimuli-responsive depolymerization

Elizabeth Gillies is a Professor and Canada Research Chair in Chemistry and Chemical & Biochemical Engineering at the University of Western Ontario. She earned her B.Sc. from Queen's University and Ph.D. from UC Berkeley under Jean Fréchet, followed by postdoctoral work at the University of Bordeaux with Ivan Huc. Joining Western in 2006, her research focuses on biodegradable and self-immolative polymers, stimuli-responsive materials, coatings, and polymer assemblies for diverse applications. She has received awards including the Macromolecular Science and Engineering Award (CIC) and the E.W.R. Steacie Memorial Fellowship (NSERC). She is an Associate Editor at Biomacromolecules.

SELF-IMMOLATIVE POLYMERS: CHEMISTRY AND APPLICATIONS OF STIMULI-RESPONSIVE DEPOLYMERIZATION

Elizabeth Gillies^a,*

^aWestern University

Corresponding Author:egillie@uwo.ca

Abstract

Degradable polymers are of growing interest for many areas, including biomedical applications, smart materials and devices, and to address the challenges associated with plastics pollution. Significant progress has been made using backbones such as polysaccharides, polyesters, and a growing number of bio-based polymers. However, in some cases it is desirable to be able to control precisely when and where polymers degrade and to access their degradation under a diverse range of conditions. Self-immolative polymers are a growing class of degradable polymers that undergo controlled end-to-end depolymerization following a stimulus-mediated backbone or end-cap cleavage (Figure 1) (1, 2). This presentation will describe the development of self-immolative polymers based on cyclization-elimination mechanisms (3, 4) and those which depolymerize due to their low ceiling temperatures (5). Advantages and disadvantages of different backbones will be discussed. In addition, the potential application of these polymers in applications such as nanopatterning, hydrogels, and self-assemblies that can encapsulate and release nucleic acids will be presented.

Keywords: self-immolative, stimuli-responsive, degradable, hydrogel, self-assembly

Figure 1. Overall design schematic for depolymerization of a self-immolative polymer.

References

1. Gong, J.; Tavsanli, B.; Gillies, E. R. Annu. Rev. Mater. Res. 2024, 54, 47-73.

2. Deng, Z.; Gillies, E. R. JACS Au 2023, 3, 2436-2450.

3. DeWit, M. A.; Gillies, E. R. J. Am. Chem. Soc. 2009, 131, 18327–18334.

4. Deng, Z.; Gillies, E. R. Angew. Chem. Int. Ed. 2025, 137, e202420054.

5. Fan, B.; Trant, J. F.; Wong, A. D.; Gillies, E. R. J. Am. Chem. Soc. 2014, 136, 10116–10123.

Prof Dr Jian Ping Gong

Hokkaido University, Japan

Topic of Presentation:

Designing functional hydrogels via bio-inspiration

Jian Ping Gong is a Distinguished Professor at Hokkaido University. She holds a degree from Zhejiang University and a Doctorate in Engineering from the Tokyo Institute of Technology. Since joining Hokkaido University in 1993, she has become a leading figure in soft matter science. Professor Gong is the recipient of several high-profile accolades, notably the IUPAC-DSM Materials Sciences Award (2014), the Chemical Society of Japan (CSJ) Award (2022), and the APS Polymer Physics Prize (2023). Her pioneering work spans tough double-network hydrogels, self-healing systems, the mechanochemistry of self-growing hydrogels, friction and adhesion.

DESIGNING FUNCTIONAL HYDROGELS VIA BIO-INSPIRATION

Jian Ping Gong^a,*

^aHokkaido University

Corresponding Author:gong@sci.hokudai.ac.jp

Abstract

The design of soft materials, such as gels and elastomers, is inherently complex. It demands careful selection of building blocks (e.g., monomers) and precise determination of their arrangement, yielding a vast design space with myriad possible combinations. Compounding this challenge, soft materials exhibit intricate behaviors governed by the interplay of weak molecular interactions and thermal fluctuations. This complexity leads to structure-property relationships that span multiple time and length scales, with mesoscale structures being critical to the emergence of material functions. However, mimicking the multi-component, hierarchical structures of biological tissues offer a great avenue for developing innovative synthetic hydrogels. This presentation will highlight the challenges and opportunities in synthesizing hydrogels that achieve the complexity and functionality of their natural counterparts. Our discussion will cover examples, including tough double network hydrogels (1), metabolic-like hydrogels(2), and underwater adhesive hydrogels(3).

Keywords: soft materials, hydrogels, high strength and toughness, self-growth, under water adhesion

References

1. X. Y. Li, J. P. Gong, Nature Reviews Materials, 9, 380–398 (2024).
2. T. Matsuda, R. Kawakami, R. Namba, T. Nakajima and J. P. Gong, Science, 363, 504-508 (2019).
3. H. G. Liao, S. Hu, H. Yang, L. Wang, S. Tanaka, I. Takigawa, W. Li, H.L. Fan & J. P. Gong, Nature, 644, 89–95 (2025)

Prof Dr Jin Huang

Southwest University, China

Topic of Presentation:

Cellulose nanocrystal materials innovation: industrialization exploration originated from fundamental research on h-bonds network and multi-level asymmetry

Mr. Jin Huang obtained Ph.D degree in Wuhan University, and serves as the full-professor in Southwest University (China). He carried out scientific research at Institute of Chemistry (CAS), Wuhan University of Technology, Institut National Polytechnique de Grenoble. He focuses on "Polymer-Centered Soft-Matter Materials" and "Sustainable Chemistry and Materials" for biomass resources utilization, structure-function integration, etc. The research on "cellulose nanocrystals-based materials" achieved progress including high-performances strategies of nanocomposites, optical enhancement of non-conjugate assemblies, and ordered long-range promotion of asymmetrical porous materials. So far, he has published over 270 peer-reviewed papers, and edited 3 monographs and wrote 8 book chapters.

CELLULOSE NANOCRYSTAL MATERIALS INNOVATION: INDUSTRIALIZATION EXPLORATION ORIGINATED FROM FUNDAMENTAL RESEARCH ON H-BONDS NETWORK AND MULTI-LEVEL ASYMMETRY

Huang Jin^a,b,* ,Lin Gan^a,*

^aSouthwest University,

^bShihezi University

Corresponding Author:huangjin@iccas.ac.cn, swucgl@swu.edu.cn

Abstract

Cellulose nanocrystals (CNCs) have garnered significant attention due to unique 1D rod-like asymmetrical morphology highly crystallinity with inner dense H-bonds, and remarkable surface reactivity, laying the foundation for material innovation and industrialization. Moreover, their commendable biocompatibility, biodegradability and biomass-acquisition endeavor competitiveness in sustainability. We have been consistently exploring diverse strategies to propel the exploration of innovative materials centered around H-bonds network in CNCs, as well as multi-level asymmetry of nanoparticles, assembled arrays, and manufactured porous materials. Primarily, the repertoire of surface chemical modification techniques and controllability strategies for CNC has expanded significantly to consolidate the substance and structure basis of materials development. Beyond manipulating molecular structures and physicochemical properties, the methodology extends to spatial and functional effects-oriented "surface molecular engineering" depending upon rigid support and ordered active sites derived from crystalline with ordered chain arrangement; and, especially to overlay the molecular asymmetry level of functional groups distribution on the surface of asymmetrical rigid CNC rod. Therefore, combined with surface modification methods, the nanoparticle-level asymmetry of CNC contributes to specific cellular endocytosis for delivery carrier, curvature difference effect for magnetic and photothermal enhancement, etc., and achieves predominant mechanical enhancement with low loading-level percolation for “nanocomposite” materials. Integrated with H-bonds network, the asymmetry researches of CNC-based materials are advanced as uniaxial orientation array-level for structural monochrome of “assembly” materials, and as orientation and negative Poisson's ratio macroscopic porous-level for electromechanical conversion elevation of constructing long-range order in “manufacturing” materials. These endeavors collectively serve as the cornerstone for the imperative integration of CNCs in industrial products. In summary, our investigations have not only shed light on the exceptional properties of cellulose nanocrystals but have also facilitated the emergence of cutting-edge methodologies for their utilization in diverse industrial applications.

Keywords: Cellulose Nanocrystals, Asymmetry, H-bonds network, Materials Innovation, Industrialization Exploration

References

1. Li, S; Liu, C.; Chen, W.; Huang, J.; Gan, L. Adv. Funct. Mater., 2025, 2418425.

2. Shi, Z.; Yang, D.; Zhou, Y.; Chen, X.; Gan, L.; Huang, J. Carbohydr. Polym., 2024, 324, 121539.

Prof Dr Makoto Ouchi

Kyoto University, Japan

Topic of Presentation:

Library synthesis of precision polymers via rational monomer design

Makoto Ouchi received his Ph.D. degree from Kyoto University in 2001. He then joined Toyota Central R&D Labs, where he engaged in the development of poly(lactic acid)–based automotive resins. In 2004, he moved to Kyoto University and began his academic career as an Assistant Professor. He was promoted to Associate Professor in 2010 and subsequently served as a PRESTO researcher of the Japan Science and Technology Agency (JST) in the “Molecular Technology” program (2013–2017). In August 2017, he was appointed Professor in the Department of Polymer Chemistry, Graduate School of Engineering, Kyoto University. He currently serves as an Associate Editor of Polymer Journal. His research interests focus on precision polymerization to explore the fundamental nature of polymers.

LIBRARY SYNTHESIS OF PRECISION POLYMERS VIA RATIONAL MONOMER DESIGN

Makoto Ouchi^a,*

^aKyoto University

Corresponding Author:ouchi.makoto.2v@kyoto-u.ac.jp

Abstract

We have rationally designed pendant-transformable monomers to enable the library synthesis of precision polymers derived from commodity monomers while incorporating diverse pendant functionalities. Through careful pendant-group design, steric repulsion during propagation induces either cross-over or helical growth, leading to alternating sequence control or isotactic regularity. Importantly, these monomers retain high reactivity toward nucleophilic transformation by alcohols and/or amines. As a result, post-polymerization modification (PPM) via quantitative alcoholysis or aminolysis allows the efficient library synthesis of alternating copolymers and isotactic polymers bearing a wide variety of pendant groups. Systematic comparison with the corresponding random copolymers or atactic polymers reveals the effects of sequence and tacticity on the resulting physical properties. In addition, our approach has been extended to the library synthesis of degradable polymers that periodically incorporate degradable trigger units.

Keywords: Radical Polymerization, Sequence, Tacticity, Degradation, Library Synthesis

References

1. Shibata, K.; Kametani, Y.; Daito, Y.; Ouchi, M., J. Am. Chem. Soc. 2022, 144, 9959-9970.

2. Pan, Y.; Ouchi, M., Angew. Chem., Int. Ed., 2023, 62, e202308855.

3. Kuroda, K.; Ouchi, M. Angew. Chem., Int. Ed., 2024, 63, e202316875.

4. Pan, Y.; Ouchi, M., Commun. Chem., 2025, 8, 259.

5. Kuroda, K.; Ouchi, M. J. Am. Chem. Soc., 2025, 147, 39632–39639.

Prof Dr Mitsuo Sawamoto

Chubu University / Kyoto University, Japan

Topic of Presentation:

Sustainable polymer science and materials: challenges and perspective

Education: B.S. (1974), M.S. (1976), and Ph.D. (1979) in polymer chemistry, Kyoto University.

Professional Career: Visiting scientist, The University of Akron, U.S.A. (1980–81); Assistant Professor (1981-91), Associate Professor (1993-94), and Professor (1994-2017), Department of Polymer Chemistry, Kyoto University; Professor (2017-24), Executive Advisor (2024-26), and Fellow (2026-), Frontier Research Institute Chubu University. Member, The Science Council of Japan (2002-); President, The Society of Polymer Science, Japan (SPSJ; 2008-10); Executive Program Director, The Japan Science and Technology Agency (JST) (2014-24); and Executive Director, The Chemical Society of Japan (CSJ; 2017-24).

Research: > 525 original papers; > 52 reviews; > 46 patents; total citation, >28,000 times (55 papers with >100 citations); h-Index 78.

Awards: SPSJ Award (1992); CSJ Divisional Research Award (1999); ACS Arthur K. Doolittle Award (2002); Macro Group UK Medal (2012); SPSJ Award for Outstanding Achievement (2013); Alexander von Humboldt Research Award (2016); Benjamin Franklin Medal in Chemistry (2017); SPSJ Honorary Membership (2019); Clarivate Citation Laureate in Chemistry (2021).

Honors: Medal of Honor with Purple Ribbon (2015); Order of the Sacred Treasure, Gold Rays with Neck Ribbon (2025); Person of Cultural Merit (2025); and CSJ Honorary Membership (2026).

Sustainable Polymer Science and Materials: Challenges and Perspective

Mitsuo Sawamoto^a,*

^aFrontier Research Institute, Chubu University, Kasugai City, Aichi 487-8501, Japan

Corresponding Author:msawamoto@fsc.chubu.ac.jp

Abstract

“Sustainability” is now among the most critical global challenges that include global warming, resources depletion, and energy crisis. Polymer science is of course not immune to these challenges, microplastics and greeen polymirc materials in particular; it is therefore imperative to polymer science to address viable and implementable solutions for a “sustainable human society”. For polymer chemistry, the sustainability would imply sustainable polymer synthesis and sustainable polymer materials, and in my view, the “sustainable” here would be double-faceted: sustainable for society and sustainable as science and technology (Fig. 1). This Plenary Lecture will discuss these topics with recent examples, so as to find our perspective and future in polymer science and technology as well as chemical sciences.

Sustainable Polymer Synthesis. This would therefore be translated into: Polymer synthesis for sustainable society and polymer synthesis that is sustainable (as a discipline).

Polymer Synthesis for Sustainable Society will require the development of green polymer synthesis and implementable methods for polymer recycle, among others. Finding viable methods to secure sustainable carbon resources for monomers and chemicals would be most critical and imperative.

Polymer Synthesis that is Sustainable would rather be inward-looking, seeking for a survivable discipline, but to develop viable green synthetic methods for functional polymeric materials.

Sustainable Polymer Materials. This would in turn be translated into: Polymer materials for sustainable society and polymer materials that are sustainable as materials.

Polymer Materials for Sustainable Society are certainly of most imminent demands and include, among many others, a variety of separation membranes and novel materials for energy security in particular, though they themselves might not be sustainable or green.

Polymer Materials that are Sustainable implies to establish science and technology that provide sustainable polymer materials, including polymers from renewable feed stocks and biodegradable polymers; recyclable supramolecular polymers are of another emerging interest.

Keywords: Sustainable Polymer Synthesis , Sustainable Polymeric Materials , Polymers from Renewable Resources, Precision Polymer Synthesis , Polymer Recycle and Depolymerization

Fig. 1. Sustainable polymer synthesis and polymeric materials: Perspective.

Prof Dr Moon Jeong Park

Pohang University of Science and Technology, South Korea

Topic of Presentation:

End-group chemistry: pathways to network morphologies and superionic polymers

Moon Jeong Park earned her B.S and Ph.D. in Chemical Engineering from Seoul National University. She was a Postdoctoral Fellow at UC Berkeley. She joined the faculty of Chemistry at the Pohang University of Science and Technology in 2009 and became a Full Professor in 2018. Her research focuses on elucidating the interplay of morphology and transport in nanostructured charged polymer materials based on a fundamental understanding of molecular interactions. She serves as an Associate Editor for Macromolecules (ACS). Recent recognitions include the 2025 Science Prize of POSCO TJ Park Foundation of Korea, the 2024 Star (Science Technology and Researcher) Award of Ministry of Science of Korea, the 2021 American Physical Society DPOLY Fellow, 2017 American Physical Society Dillon Medal, and 2016 IUPAC Young Polymer Scientist Award, and 2016 Young Scientist Award of Ministry of Science of Korea. She was also selected as the 15th Female Scientist and Engineer of the Year Award of Korea.

END-GROUP CHEMISTRY: PATHWAYS TO NETWORK MORPHOLOGIES AND SUPERIONIC POLYMERS

Moon Jeong Park^a,*

^aPohang University of Science and Technology

Corresponding Author:moonpark@postech.ac.kr

Abstract

End-group functionalization has become a powerful and versatile strategy in polymer science, allowing precise tuning of intrinsic polymer properties, such as thermal transitions, solubility, and crystallization, without altering the polymer backbone. In our group’s work, we have shown that end-group interactions can direct polymer self-assembly, enabling the formation of thermodynamically stable, highly frustrated three-dimensional network structures. I propose revising traditional block copolymer phase diagrams to incorporate end–end interactions and end-group arrangements. When end-functionalized block copolymers exhibit strong end–end associations, network phases such as gyroid, diamond, and primitive can occupy a significantly expanded phase window, replacing the lamellar structures typically expected. This underscores the powerful role of end-group chemistry in shaping functional nanomaterials. This concept also provides a pathway for developing superionic polymers by strategically designing charged end groups that finely tune molecular interactions. Such interactions decouple ion relaxation from polymer relaxation, overcoming the trade-off between ionic conductivity and mechanical strength seen in many solid-state polymer electrolytes. These insights highlight the transformative potential of end-group chemistry for next-generation polymer materials and provide a foundation for designing functional nanomaterials for emerging applications, including solid-state battery electrolytes, mechanical metamaterials, and optical metamaterials.

Keywords: End-Group functionalization

References

1) Hojun Lee, Sangwoo Kwon, Jaemin Min, Seon-Mi Jin, Jun Ho Hwang, Eunji Lee, Won Bo Lee, and Moon Jeong Park*, “Thermodynamically Stable Plumber’s Nightmare Structures in Block Copolymers”, Science 2024, 383, 70.

2) Hojun Lee, Jihoon Kim, and Moon Jeong Park*, “Block Copolymer Electrolytes with Double Primitive Cubic Structures: Enhancing Solid-State Lithium Conduction via Lithium Salt Localization”, ACS Nano 2025, 19, 1251.

3) Xuelang Gao, Hojun Lee, Woongsik Choi, Yunsoo Shim, Hyung Min Chi, and Moon Jeong Park*, “Superionic Disulfonic Acid Polymers”, Adv. Funct. Mater. 2025, 2501998.

Prof Dr Rachel O'Reilly

University of Birmingham, United Kingdom

Topic of Presentation:

Precision polymer nanoparticles

Rachel O’Reilly is Professor of Chemistry and Pro-Vice Chancellor for Research at the University of Birmingham. She previously served as Head of the School of Chemistry and spent a decade at the University of Warwick. She has held major fellowships from the EPSRC, Royal Society and ERC. O’Reilly earned her undergraduate degree from the University of Cambridge and completed her PhD at Imperial College London in 2003. Her research focuses on catalysis, responsive polymers, advanced materials, nanostructure characterization and DNA nanomaterials. She has published nearly 300 papers and received numerous honors, including the 2025 Tilden Medal and election to the Royal Society in 2022.

PRECISION POLYMER NANOPARTICLES

Rachel O'reilly^a,*

^aUniversity of Birmingham

Corresponding Author:r.oreilly@bham.ac.uk

Abstract

Crystallization-driven self-assembly (CDSA) is a powerful tool in the solution polymer self-assembly toolbox and has been utilized to create an impressive range of hierarchical block copolymer structures. Unlike in conventional solution self-assembly, where the range of morphologies obtained are determined by varying the relative block composition of each block, in polymers assembled via CDSA, the formation of micelles with low interfacial curvature is favored. However, despite advances in CDSA there are relatively few examples where the aggregate morphology can be readily controlled to form nanostructures whose size can be controlled in 2 dimensions. Our group has the CDSA of poly(ester) based block copolymers. In this work we present the CDSA of a range of polylactone block copolymers which form a range of self-assembled nanostructures including 2D nanostructures. Using these we have further explored the design rules for the synthesis of such 2D nanomaterials and demonstrated their epitaxial growth, which highlights their potential as biocompatible nanomaterials.

Keywords: CDSA

References

Prof Dr Andrew Whittaker

The University of Queensland, Australia

Topic of Presentation:

Sulfoxide polymers as nanomedicines

Andrew Whittaker is ARC Australian Professorial Fellow and professor of polymer physical chemistry within the Australian Institute for Bioengineering and Nanotechnology at The University of Queensland. His group conducts research into materials for microelectronics and for health. Whittaker has held numerous leadership roles including as President of the Pacific Polymer Federation and the Australian RACI National Polymer Division, amongst other roles. He has published over 500 refereed journal articles, has extensive collaborations with industry, and has licensed his technology to multinational corporations. Whittaker has graduated over 75 PhD students, many of whom are now in leadership positions on four continents.

SULFOXIDE POLYMERS AS NANOMEDICINES

Andrew Whittaker^a,* ,Changkui Fu^a

^aThe University of Queensland

Corresponding Author:a.whittaker@uq.edu.au

Abstract

Polymer-based therapeutics are increasingly being used for the treatment of a range of diseases including cancer. However, their rapid clearance from the body and immunogenicity often hinder successful clinical outcomes. The formation of conjugates with poly(ethylene glycol) (PEG) is the most commonly used strategy to improve the in vivo pharmacokinetic profile of therapeutics by providing "stealth" properties. Despite the desirable outcomes offered by PEG, the immunogenicity and hypersensitivity that are found to be associated with PEG have generated concerns, prompting the development of alternative polymers for protein conjugation. As part of this effort we have introduced a series of polymers containing the highly hydrophilic sulfinyl moiety, for example poly(2-(methylsulfinyl)ethyl acrylate, PMSEA. Initially we found that oxidation of thioethers on acrylate polymers produced a change in solubility and that this could be exploited to develop responsive MRI agents.¹ On further recognizing the potential of this class of polymer for imparting high levels of hydration to materials, we demonstrated the use of PMSEA and derivatives as PEG alternatives in nanomedicines.^2-4 More recently we have examined the use of low-fouling PMSEA within polymer-lipid conjugates to prepare low immunogenic lipid nanoparticles. Finally we have shown that grafting of sulfinyl polymers onto substrates has been shown to dramatically reduce protein adhesion and cell attachment,⁵ and applications in medical devices are being explored.

Keywords: sulfoxide polymers, low-fouling surfaces, delivery, MRI

References

1. 1. Fu, C.; Herbst, S.; Zhang, C.; Whittaker, A. K., Polym. Chem. 2017, 8 (31), 4585-4595.
2. 2. Qiao, R.; Esser, L.; Fu, C.; Zhang, C.; Hu, J.; Ramirez-arcia, P.; Li, Y.; Quinn, J. F.; Whittaker, M. R.; Whittaker, A. K.; Davis, T. P., Biomacromolecules 2018, 19 (11), 4423-4429.
3. 3. Fu, C.; Demir, B.; Alcantara, S.; Kumar, V.; Han, F.; Kelly, H. G.; Tan, X.; Yu, Y.; Xu, W.; Zhao, J.; Zhang, C.; Peng, H.; Boyer, C.; Woodruff, T. M.; Kent, S. J.; Searles, D. J.; Whittaker, A. K., Angew Chem Int Ed Engl 2020, 59 (12), 4729-4735.
4. 4. Wang, Q.; Yu, Y.; Chang, Y.; Xu, X.; Wu, M.; Ediriweera, G. R.; Peng, H.; Zhen, X.; Jiang, X.; Searles, D. J.; Fu, C.; Whittaker, A. K., ACS Nano 2023, 17 (9), 8483-8498.
5. 5. Xu, X.; Huang, X.; Chang, Y.; Yu, Y.; Zhao, J.; Isahak, N.; Teng, J.; Qiao, R.; Peng, H.; Zhao, C.-X.; Davis, T. P.; Fu, C.; Whittaker, A. K., Biomacromolecules 2021, 22 (2), 330-339.

Prof Dr Atsushi Kajiwara

Nara University of Education, Japan

Topic of Presentation:

Direct observation of radicals in radical polymerizations using electron spin resonance spectroscopy for deeper understanding of radical polymerizations and reactions

A distinguished scholar in Macromolecular Science, this individual earned their B.S., M.S., and Ph.D. from Osaka University. Currently serving as a Professor at Nara University of Education, their extensive career includes significant international research roles at Carnegie-Mellon University and Peking University.

Their primary research expertise lies in ESR spectroscopy, specifically investigating radical polymerizations and developing innovative educational materials. This impactful work earned them the prestigious SPSJ Award for Outstanding Paper in 1995, followed by the 2017 SPSJ Award for their fundamental research contributions to the field of polymer science and electron spin resonance.

DIRECT OBSERVATION OF RADICALS IN RADICAL POLYMERIZATIONS USING ELECTRON SPIN RESONANCE SPECTROSCOPY FOR DEEPER UNDERSTANDING OF RADICAL POLYMERIZATIONS AND REACTIONS

Atsushi Kajiwara^a,*

^aNara University of Education

Corresponding Author:kajiwara@cc.nara-edu.ac.jp

Abstract

While many researchers study the control of polymerization reactions in the field of radical polymerization, very few study the radicals themselves—the active species in the reaction.

Radicals can be observed as spectra using electron spin resonance (ESR) spectroscopy. Time resolved ESR (TR-ESR) allows for the exclusive observation of the reaction initiation process when observing the same polymerization system, while steady-state ESR (SS-ESR) enables the observation of growing radicals. Both methods allow discussions of not only the structure and dynamic behavior of radicals at each stage, but also reaction kinetics.

TR-ESR allows for a deeper investigation of the fundamental properties of radicals. When using TR-ESR to observe only acylphosphine oxide, a commonly used initiator, a spectrum like the one shown in Figure 2 is obtained. The initiator remains the same; only the solvent differs. Unlike SS-ESR spectra, TR-ESR spectra are obtained in the form of microwave absorption or emission. In Figure 2, the upward direction represents absorption and the downward direction represents emission. In benzene, all signals are observed in the upward direction (i.e., absorption); in ionic liquids, however, the low-field side is observed in the downward direction (emission), while the high-field side is observed in the upward direction (absorption). This difference is based on the distinct spin states of the electrons. In SS ESR, electrons are merely observed as unpaired, but in TR ESR, the spectrum reflects their spin states. The fact that the spin state changes with variations in temperature and solvent indicates that a more in-depth discussion of radical polymerization reactions is possible.

Keywords: radical polymerization, ESR, time-resolved ESR, ionic liquid

Figure 1 TR- and SS-ESR spectra, along with the results of radical polymerizations.

Figure 2 TR ESR spectra of acylphosphine oxide in benzene (top) and in an ionic liquid (bottom).

References

1. Atsushi Kajiwara, Time-Resolved ESR Method for Observing Rapid Radical Reactions, JEOL News, 2025, 60, 28-36.

Prof Dr Atsushi Sudo

Kindai University, Japan

Topic of Presentation:

Synthesis of high performance polymers from naturally occurring myo-inositol

Atsushi Sudo received his BEng, MEng, and PhD degrees from the University of Tokyo (1988–1997). After serving as a technical assistant and assistant professor at Tokyo Institute of Technology, he joined Kindai University in 2002, where he is currently Professor in the Faculty of Science and Engineering. His scientific background spans organic chemistry, asymmetric synthesis, polymer synthesis, and polymer reactions. His current research focuses on the development of high-performance polymers derived from naturally occurring compounds, aiming at sustainable and functional polymeric materials.

SYNTHESIS OF HIGH PERFORMANCE POLYMERS FROM NATURALLY OCCURRING MYO-INOSITOL

Atsushi Sudo^a,*

^aKindai University

*Corresponding Author:asudo@emat.kindai.ac.jp

Abstract

Efforts to develop bio-based polymers have intensified to replace petroleum-based materials. Rigid diols from natural compounds are promising for producing heat-resistant polymers, as their rigid structures restrict chain motion and increase glass transition temperatures (T_g).

We focus on myo-inositol, a renewable resource from nonedible biomass such as rice bran and bean skins. Regioselective modification of its hydroxyl groups yields rigid derivatives, including cyclic acetals and orthoesters. Orthoester 1, a triol with an adamantane-like motif, serves as a precursor for rigid monomers [1].

This study describes the conversion of 1 into diols 2 and 3 and their polyadditions to form high-Tg polymers. Diol 2 is obtained via reaction with phenyl isocyanate, and its polyaddition with hexamethylene diisocyanate (HMDI) yields polyurethanes with Tg comparable to isosorbide-based systems [1]. Diol 3 is prepared by acetalization of two axial hydroxyl groups, forming cyclic acetals that enhance rigidity [2]. Its polyaddition with diisocyanates produces polymers with high adamantane-like content, demonstrating its potential for high-Tg bio-based materials.

Keywords:bio-based polymers, rigid diols, myo-inositol, high-Tg polymers

Prof Dr Bumjoon Kim

Korea Advanced Institute of Science & Technology, South Korea

Topic of Presentation:

Overcoming trade-off between electrical and mechanical properties of conjugated polymers: intrinsically-stretchable polymer solar cells

Bumjoon Kim is a KAIST Endowed Chair Professor in the Department of Chemical and Biomolecular Engineering at KAIST. He also served as a Department Head from 2021 to 2025. He has published 370 SCI papers with a H-index of 90 and a citation number of > 28000. He is a Fellow of the Korean Academy of Science and Technology (KAST), a member of National Academy of Engineering of Korea (NAEK) and a Fellow of the Royal Society of Chemistry (FRSC).

OVERCOMING TRADE-OFF BETWEEN ELECTRICAL AND MECHANICAL PROPERTIES OF CONJUGATED POLYMERS: INTRINSICALLY-STRETCHABLE POLYMER SOLAR CELLS

Bumjoon Kim^a,*

^aKorea Advanced Institute of Science & Technology (KAIST)

*Corresponding Author:bumjoonkim@kaist.ac.kr

Abstract

Considering the technical standards (e.g., mechanical robustness) required for wearable electronics, which are promising application platforms for organic solar cells, the development of fully stretchable OSCs (f-SOSCs) should be accelerated. First, the mechanical requirements of f-SOSCs, in terms of tensile and cohesion/adhesion properties, are summarized along with the experimental methods to evaluate those properties. Second, important studies to make each layer of f-SOSCs stretchable and efficient are discussed, emphasizing strategies to simultaneously enhance the photovoltaic and mechanical properties of the active layer. For example, I present material design strategies to enhance the mechanical robustness of the PSCs as well as their power conversion efficiencies (PCEs); i) incorporating a high-molecular weight polymer acceptor as an electro-active additive into binary blends, ii) design of hydrogen-bonding incorporated polymers, and iii) design of block copolymerized electroactive polymers. With these contributions, the f-SOSCs with over 14% PCE and excellent stretchability are developed. In addition, I will present the example of strain-induced power enhancement using these f-SOSCs.

Keywords:Photoactive Polymers; Polymer Solar Cells; Stretchable Devices

Prof Dr Christine Luscombe

Okinawa Institute of Science and Technology, Japan

Topic of Presentation:

Synthesis as a tool for expanding the scope of semiconducting polymers

Christine Luscombe is a Professor at the Okinawa Institute of Science and Technology. She earned her B.A. and Ph.D. from the University of Cambridge and was a postdoctoral fellow at UC Berkeley. She began her independent career at the University of Washington, where she is now an Elected Member of the Washington State Academy of Sciences (2020). Prof. Luscombe’s research on the synthesis of semiconducting polymers and the study of microplastics has led to over 140 publications. Her work has been recognized with awards such as the NSF CAREER Award, DARPA Young Faculty Award, Sloan Research Fellowship, the Society of Synthetic Organic Chemistry of Japan Lecture Award (2017), the Society of Polymer Science Japan Science Award (2022), the Jean-Marie Lehn Award (2024), and Dresselhaus Memorial Lectureship Award (2026). She is currently Editor-in-Chief for Polymer Chemistry, and serves on the Board of Directors for MRS and the Board for Society of Polymer Science Japan. She is the Vice President (President-elect) of IUPAC.

SYNTHESIS AS A TOOL FOR EXPANDING THE SCOPE OF SEMICONDUCTING POLYMERS

Christine Luscombe^a,*

^aChristine Luscombe

Corresponding Author:christine.luscombe@oist.jp

Abstract

The performance of semiconducting polymers is fundamentally dictated by the precision with which their molecular structure can be controlled. Therefore, advancing the synthetic toolkit is crucial for developing next-generation organic electronic materials. While traditional cross-coupling reactions have been instrumental, the field is increasingly moving towards more sustainable and atom-economical methods like direct arylation polymerization (DArP). This approach offers significant advantages, including fewer synthetic steps and reduced organometallic waste. However, achieving precise control over selectivity, molecular weight, and defects during polymerization remains a critical challenge.

To address these limitations, synergistic catalysis has emerged as a powerful strategy, utilizing cooperative catalyst systems to unlock reaction pathways and levels of control unattainable with single catalysts. This approach has enabled the development of controlled polymerizations that exhibit "living" characteristics, yielding well-defined polymers with predictable molecular weights and low dispersities.

Furthermore, this strategy has been successfully applied to overcome selectivity issues in challenging reactions such as cross-dehydrogenative coupling (CDC). By employing synergistic Pd/Ag cocatalyst systems, for instance, the synthesis of high-molecular-weight, defect-free donor-acceptor copolymers via direct C-H/C-H coupling has been achieved with exceptional selectivity. Computational studies, including DFT calculations, have provided insight into these systems, revealing that enhanced reaction rates and selectivity often stem from unique catalyst-substrate interactions that lower the activation energy barriers for C-H activation. These breakthroughs in precision synthesis are not only paving the way for superior polymeric materials but also have broad implications for the synthesis of complex organic molecules where C-H functionalization is a key challenge.

Keywords: Semiconducting polymers, Direct arylation, Kumada catalyst transfer polymerization

Prof Dr Dong June Ahn

Korea University, South Korea

Topic of Presentation:

Macromolecular assemblies for biopreservation by water-ice dynamics

Dong June AHN is the faculty of the Department of Chemical and Biological Engineering at Korea University. He was inducted in 2022 as a Fellow of both the Korean Academy of Science and Technology and the National Academy of Engineering of Korea. He has served as the President of the Korean Society for Nanomedicine (2015-16), the Secretary General of the 48th World Polymer Congress-IUPAC Macro 2020+ (2021), and he is currently the President of the Pacific Polymer Federation (2025-27). He leads the Global Engineering Research Program titled Augmented Biopreservation Center (2025-32) supported by NRF, Korea.

MACROMOLECULAR ASSEMBLIES FOR BIOPRESERVATION BY WATER-ICE DYNAMICS

Dong June Ahn^a,* ,Tae-Kyung Won^a ,Woo Hyuk Jung^a ,Sang Yup Lee^a ,Yedam Lee^a

^aKorea University

Corresponding Author:ahn@korea.ac.kr

Abstract

Water freezing is a commonly observed natural phenomenon; however, ice growth and recrystallization can critically damage living organisms. Nature has evolved to produce antifreeze proteins to survive this freezing threat. Their specific amino acid sequence has been widely accepted to play a critical role in binding to ice, which can result in antifreeze activity. On the contrary, ice-binding surfaces can also lead to heterogeneous ice nucleation when the appropriate chemical and dimensional constraints meet. Both phenomena, which require hydrogen-bonding natures with ice surfaces in common, demand distinct design protocols, and thus active mimetic materials have been developed by tailoring them for respective purposes. In this presentation, we will address our recent achievements based on the strategic designs of hydrogen-bonding nature and the dynamics of the water-ice interface of the hydrogen-bonding natures at the water-ice interface by unique nanoscale assemblies and macromolecules with surface and topological engineering.

Keywords: Macromolecules, Water-Ice Dynamics, Biopreservation

References

1. S.Y. Lee, M. Kim, T.K. Won, S.H. Back, Y. Hong, B.-S. Kim*, D.J. Ahn*, “Janus Regulation of Ice Growth by Hyperbranched Polyglycerols Generating Dynamic Hydrogen Bonding”, Nat. Commun., 2022, 13, 6532.
2. M. Lee, S.Y. Lee, M.-H. Kang, T.K. Won, S. Kang, J. Kim, J. Park*, D.J. Ahn*, “Observing Growth and Interfacial Dynamics of Nanocrystalline Ice in Thin Amorphous Ice Films”, Nat. Commun., 2024, 15, 908.
3. T.K. Won, A. Shin, S.Y. Lee, B.-S. Kim*, D.J. Ahn*, “Na⁺-Complexed Dendritic Polyglycerols for Recovery of Frozen Cells and Their Network in Media”, Adv. Mater., 2025, 37, 2416304.
4. W.H. Jung, S.Y. Lee, Y. Lee, D.J. Ahn*, “Freezing-Driven Ionic Charge Imbalance Leads to Pore Formation and Osmotic Injury of Lipid Membranes”, Computers in Biology and Medicine, 2025, 189, 109960.
5. Y. Lee, W.H. Jung, K. Jeon, E.B. Choi, T. Ryu, C. Lee*, D.-N. Kim*, D.J. Ahn*, “Membrane-targeted DNA Frameworks with Biodegradability Recover Cellular Function and Morphology from Frozen Cells", Trends in Biotechnology, 2025, 43, 3196.

Prof Dr Ishak Ahmad

Universiti Kebangsaan Malaysia, Malaysia

Topic of Presentation:

Cellulose nanocrystal (cnc)-based hydrogels and aerogels: design, properties and applications

Prof. ChM. Dr. Ishak bin Ahmad is a distinguished expert in polymer science, specializing in natural polymers. His research has been widely published in high-impact journals, including Progress in Polymer Science, with over 10,000 citations and an H-index of 46. He is listed among the world’s Top 2% Scientists by Stanford University and has received multiple Malaysia’s Research Star Awards (MRSA). He holds several international appointments, including Visiting Professor and Research Fellow positions, and has delivered numerous keynotes, plenary, and invited lectures. Nationally, he is a Fellow of the Academy of Sciences Malaysia and active in professional bodies. He currently serves as Dean of the Faculty of Science and Technology at UKM, with extensive leadership and academic evaluation experience. He is also actively involved in community engagement programmes with industries and local communities.

CELLULOSE NANOCRYSTAL (CNC)-BASED HYDROGELS AND AEROGELS: DESIGN, PROPERTIES AND APPLICATIONS

Ishak Ahmad^a,*

^aUniversiti Kebangsaan Malaysia (UKM)

Corresponding Author:gading@ukm.edu.my

Abstract

Cellulose nanocrystals (CNCs) have emerged as highly attractive bio-based nanomaterials for the development of advanced hydrogels and aerogels due to their renewability, high crystallinity, tunable surface chemistry, and excellent reinforcing capability. This abstract highlight the design strategies, structure–property relationships, and multifunctional applications of CNC-based hydrogels and aerogels, with particular emphasis on environmentally friendly fabrication approaches. CNC-based aerogels are commonly engineered through surface modification techniques, such as silane grafting, to impart hydrophobic–oleophilic characteristics, while biopolymers like gelatin are employed as binders to enhance structural integrity. Gamma irradiation plays a crucial role as a green crosslinking and polymerization technique, eliminating the need for toxic chemical crosslinkers and enabling precise control over network formation by adjusting radiation dose. Morphological studies reveal that gamma-irradiated CNC aerogels exhibit well-organized, interconnected porous structures, which contribute to improved mechanical strength, high oil absorption capacity, and excellent reusability. Surface analyses demonstrate a significant reduction in hydroxyl groups and increased water contact angles following silane modification, confirming enhanced hydrophobicity suitable for oil–water separation applications. In parallel, CNC-reinforced hydrogels exhibit superior mechanical performance and stimuli-responsive behavior compared to microcellulose-filled systems. The high crystallinity and nanoscale dimensions of CNCs enhance storage modulus, pore homogeneity, and interfacial interactions within polymer networks such as poly(acrylic acid) and gelatin. These hydrogels display pronounced responsiveness to pH and temperature changes, highlighting their potential in smart materials, biomedical devices, and controlled release systems. Overall, CNC-based hydrogels and aerogels represent a versatile class of sustainable materials whose properties can be tailored through irradiation-assisted crosslinking and surface modification, enabling applications ranging from environmental remediation to responsive soft materials.

Keywords: cellulose nanocrystals (CNC), hydrogels, aerogels, nanocomposite

References

1. Safar, H.; Ahmad, I.; Ramli, S.; Mohamed, F.; Daniel Thangadurai, T.; Thomas, S. 2025. Heliyon. 11, e42615.
2. Rosli, N.A.; Khairudin, F.A.; Kargarzadeh, H.; Othaman, R.; Ahmad, I.. 2022. Inter. J. Bio. Macro. 213-223.
3. Salleh, A.; Mustafa, N.; Teow, Y.H.; Fatimah, M.N.; Khairudin, F.A.; Ahmad I.; Fauzi*, M.B. 2022. Biomedicines. 10, 816.
4. Wan Ishak, W.H.; Rosli, N.A.; Ahmad. I.; Ramli, S.; Mohd Amin, M.C.I. 2021. J. Mater Research Technol. 15, 7145–7157.
5. Rosli, N.A., Wan Ishak, W.H., Ahmad, I. 2021. J. Cleaner Production, 290, 125886. doi.org/10.1016/j.jclepro.2021.125886

Prof Dr Kohzo Ito

Tokyo University, Japan

Topic of Presentation:

Slide-ring vitrimer and biodegradable nylon6/66

Kohzo Ito is University Professor at The University of Tokyo and Fellow at National Institute for Materials Science. He received his B. E, M. E. and Ph. D. degrees in applied physics from The University of Tokyo. He was the president of the Society of Polymer Science, Japan, and is running flagship national projects as a program director (SIP) and project manager (Moonshot Program). He has been researching the polymer physics and supramolecular chemistry, and now is focusing on slide-ring materials from polyrotaxane using cyclodextrin, necklace-like supramolecule with topological characteristics.

SLIDE-RING VITRIMER AND BIODEGRADABLE NYLON6/66

Kohzo Ito^{a, b,*}, Shota Ando^a

^aThe University of Tokyo,

^bNational Institute for Materials Science

*Corresponding Author:kohzo@k.u-tokyo.ac.jp

Abstract

We have found that the Slide-Ring Materials^1,2) by cross-linking polyrotaxane (PR) and epoxy resin vitrimers drastically improved the mechanical properties, self-healing, chemical decomposition, and marine biodegradability of vitrimers.³⁾ The optimal vitrimer with PR exhibited enhanced toughness, with an elongation at break 5.3 times greater than that of a vitrimer devoid of PR; it also showed self-healing properties, was chemically recycled 10 times faster, and was recovered twice as fast. These results are ascribable to the sliding diffusion motion of the PR, which lowers the energy required for transesterification. Furthermore, vitrimer-containing PR showed 25 wt.% biodegradation following exposure to seawater for 30 d. These findings may lead to the development of environment-friendly plastics that exhibit most of the properties required for a sustainability.

Microplastics in the marine environment have emerged as a pressing global issue. Fishing lines pose a particularly formidable challenge, as their resistance to biodegradation in seawater has led to significant harm to marine turtles, seabirds, and fish. Furthermore, polymers that have been engineered for marine biodegradability, such as polyhydroxyalkanoates, show inadequate mechanical strength for widespread application in fishing lines. In this study, we report the unexpected discovery that certain commercially available nylon materials, nylon 6 and nylon 6,6 copolymers, previously believed to be nonbiodegradable, can in fact undergo biodegradation in marine conditions.⁴⁾ Our findings offer a promising solution to the environmental concerns associated with fishing lines and may have broader applications (e.g. fishing nets). This discovery represents a breakthrough in the development of marine-biodegradable polymers that successfully balance durability, strength, toughness, cost, and mass-productivity with environmental degradability.

Keywords:Slide-Ring Materials, Polyrotaxane, Vitrimer, Biodegradable, Nylon

References

1. Okumura, Y.; Ito, K. Adv. Mater. 2001, 13, 485-487.

2. Liu, C.; Morimoto, N.; Jiang L.; Kawahara, S.; Noritomi, T.; Yokoyama, H.; Mayumi, K.; Ito, K. Science 2021, 372(6546), 1078-1081.

3. Ando, S.; Hirano, M.; Wakatabe, L.; Yokoyama, H., Ito K. ACS Mater. Lett. 2023, 5, 3156-3160.

4. Ando, S: Kasai, D.; Masaki M.; Ueno, E.; Akiyama M.; Gibu, N.; An, Yingjun; Kikuchi T.; Yonemura, M.; Kato, D.; Hinata, H.; Takahara A.; Ito, K. ChemRxiv 2025 DOI: 10.26434/chemrxiv-2025-cbmb0.

Prof Dr Kotaro Satoh

Institute of Science Tokyo, Japan

Topic of Presentation:

New polymerization system of chain-growth controlled/"living" click polymerization

Kotaro Satoh is a Professor at Institute of Science Tokyo (formerly Tokyo Institute of Technology) and an Associate Editor of ACS Sustainable Chemistry & Engineering. He received his Ph.D. in polymer chemistry from Kyoto University in 2000 under M. Sawamoto. After working at Kuraray Co., Ltd. (2000–2004), he joined Nagoya University with M. Kamigaito, becoming Associate Professor in 2007. He was a visiting scientist at the University of California, Santa Barbara, with C. J. Hawker (2009). His research focuses on precision polymerization and sustainable polymers from renewable vinyl monomers.

NEW POLYMERIZATION SYSTEM OF CHAIN-GROWTH CONTROLLED/"LIVING" CLICK POLYMERIZATION

Kotaro Satoh^a,*

^aInstitute of Science Tokyo

Corresponding Author:satoh@mct.isct.ac.jp

Abstract

Recently, we have reported a new class of controlled/"living" polymerization system, which proceeds bidirectional fashion using click reaction of AB monomer bearing azide and alkyne functionalities in a single molecule. This click polymerization of the AB monomer proceeded well using both azide and alkyne initiators in the well-controlled manner in either growth direction to afford polymers with predetermined molecular weights and narrow molecular weight distributions as well as the terminal structures inherited from the initiator. Especially, the polymerizations with the difunctional initiators provided well-defined linear polymers with azide or alkyne groups at both termini.[1] This approach also allows for polymerization control over the second monomer to give a block copolymer. In addition, simple propargyl amines are reported as the initiator for controlled/"living" click polymerization, some of which are commercially available and contribute to even simpler polymerization processes. By employing tripropargyl or dipropargyl amine, the polymerization of azide-alkyne AB monomer proceeded well in a well-controlled manner, which was comparable to that with complicated initiators.[2]

Keywords: Living Polymerization, Click Reaction, Chain Growth Polymerization, Bi-Directional, Block Copolymerization

References

1. S. Sakai, T. Nakamura, S. Uchida, Y. Nakauchi, M. Uchiyama, T. Kubo, M. Kamigaito, K. Satoh*, J. Am. Chem. Soc., 2025, 147, 21459–21467.
2. S. Sakai, Y. Yamazaki, T. Kubo, K. Satoh, J. Polym. Sci., 2025, 63, 19, 3892-3899.

Prof Dr Pauline Pei Li

The Hong Kong Polytechnic University, Hong Kong, China

Topic of Presentation:

Amphiphilic core-shell and composite particles for biomedical applications

Professor Pei Li received her Ph.D. in Chemistry from the University of Ottawa, Canada, in 1990. She has been with The Hong Kong Polytechnic University for nearly 35 years. Her research spans a broad range of topics, with a primary focus on the molecular design and synthesis of novel materials. She specializes in the development of advanced polymers and composite particles for diverse applications, including controlled drug delivery, gene therapy, bio-imaging, enzyme immobilization, biomolecular and chemical separations, functional coatings, and wastewater treatment.

AMPHIPHILIC CORE-SHELL AND COMPOSITE PARTICLES FOR BIOMEDICAL APPLICATIONS

Pei Li^a,*

^aThe Hong Kong Polytechnic University

Corresponding Author:pei.li@polyu.edu.hk

Abstract

Nanoparticles have emerged as important functional materials in modern medicine and biology, with broad applications as drug and gene delivery vehicles, imaging contrast agents, and biosensors. Their performance in biological systems is governed not only by their size and composition, but also, critically, by the interfacial interactions that occur between the nanoparticle surface and the surrounding biological environment. These interactions strongly influence cellular uptake, circulation behavior, biodistribution, therapeutic efficacy, and potential toxicity. Therefore, the rational design and synthesis of nanoparticles with well-controlled surface chemistry and tunable interfacial properties are essential for the development of safe and effective nanomedicine platforms.

This presentation focuses on the design of amphiphilic polymer-based core-shell nanoparticles and hybrid nanocomposite particles for biomedical applications. In the first part, polyethyleneimine (PEI)-based core-shell nanocarriers are introduced as promising systems for gene delivery. By combining the strong nucleic acid binding capability of PEI with amphiphilic structural features and controlled surface functionality, these nanocarriers can improve gene loading, enhance cellular internalization, and reduce the cytotoxicity commonly associated with cationic polymers. Such properties make them attractive candidates for non-viral gene delivery applications. In the second part, magnetic-responsive nanocomposite particles are discussed for use in magnetic resonance imaging (MRI) diagnosis. These particles integrate polymeric and magnetic components into a single platform, enabling responsive behavior, improved colloidal stability, and enhanced imaging performance. The composite structure also offers opportunities for multifunctionality, including simultaneous imaging and therapeutic delivery.

Keywords:Amphiphilic, Core-Shell Nanoparticles, Gene delivery, Magnetic-responsive nanoparticle

References

1. Jia, Y., Niu, D., Li, Q., ; Huang, H., ; Li, X., Li, K., Li, L., Zhang, C., Zheng, H., Zhu, Z., Yao, Y.,Zhao, X., Li, P., Yang, G,. Nanoscale2019, 11, 2008-2016.

2. Liao, J., Zhou, L., Wu, Y., Qian, Z., Li, P. Nanoscale Advances 2024, 6, 3367–3376.

Prof Dr Peter Cormack

University of Strathclyde, United Kingdom

Topic of Presentation:

Beaded organic polymers go with the flow

Peter Cormack is Professor of Polymer Chemistry and Head of Materials & Computational Chemistry at the University of Strathclyde in Glasgow, Scotland, UK. Peter has built a global reputation as international leader in polymer science, and he is motivated by a desire to pursue useful polymer chemistry research which promises tangible, societal benefits. Peter’s research interests lie predominantly in the areas of synthetic polymer chemistry and materials science, with special emphasis on the design, synthesis and applications of functional organic polymers, including porous organic solids, polymeric synthetic receptors, polymer microspheres, chemical sensors and ion-exchange resins.

BEADED ORGANIC POLYMERS GO WITH THE FLOW

Peter Cormack^a,*

^aUniversity of Strathclyde

Corresponding Author:peter.cormack@strath.ac.uk

Abstract

Porous organic polymers are exploited in a broad range of specialist and everyday applications, including as polymer supports in solid-phase synthesis work and heterogeneous catalysis, as ion-exchange resins for water purification, as tissue engineering scaffolds, and as functional materials in biological assays. Furthermore, they are highly attractive for use in a number of important chemical separation scenarios, including as high-performance sorbents and stationary phases in solid-phase extraction (SPE) and chromatographic separation technologies, respectively, spanning large-scale chemical separations and analytical-scale work (e.g., the monitoring of environmental pollutants and drug molecules).

At the University of Strathclyde in Glasgow, we specialize in the design, synthesis and application of porous organic polymers, optimised to solve an array of real-world scientific problems, including challenging analytical chemistry problems (in fields of application such as environmental analysis, bioanalysis, food analysis, forensic toxicology and omics). In this lecture, I will outline how we control the physical format, porosity and chemical functionality of porous polymers tailored for high-performance chemical separation work, and explain how the polymers can be used as advanced sorbents in SPE. Typically, the polymers are synthesized by methods such as precipitation polymerization and suspension polymerization, and porosity is installed into the polymers though the use of porogenic agents and/or hypercrosslinking methodologies. Affinity and selectivity for molecular targets by the polymers is ensured through the incorporation of chemical motifs such as ion-exchange groups or molecular receptors installed through template-directed synthetic strategies such as molecular imprinting. The latter approach delivers antibody binding mimics that we apply to disease diagnosis, prognosis and management. Whilst the preferred mode of operation for the exploitation of our beaded polymers is normally liquid flow through packed beds, our micron-sized beaded products are well-suited for circulation through microfluidics devices.

Keywords: Microspheres, Porosity, Ion-exchange, Molecular imprinting, Solid-phase extraction

References

1. Polymer-Supported Photosensitizers for Oxidative Organic Transformations in Flow and Under Visible Light Irradiation, J.M. Tobin, T.J.D. McCabe, A. Prentice, S. Holzer, G.O. Lloyd, M.J. Paterson, V. Arrighi, P.A.G. Cormack and F. Vilela, ACS Catal. (2017) 7, 4602-4612

2. Magnetic Synthetic Receptors for Selective Clean-Up in Protein Biomarker Quantification, N. McKitterick, F. Braathen, M.A. Świtnicka-Plak, P.A.G. Cormack, L. Reubsaet and T.G. Halvorsen, J. Proteome Res. (2020) 19(8), 3573

3. Microporous Polymer Microspheres with Amphoteric Character for the Solid-Phase Extraction of Acidic and Basic Analytes, J.C. Nadal, K.L. Anderson, S. Dargo, I. Joas, D. Salas, F. Borrull, P.A.G. Cormack, R.M. Marcé and N. Fontanals, J. Chromatogr. A (2020) 1626, 461348

4. Donor-Acceptor Stenhouse Adduct Functionalised Polymer Microspheres, J.P. Wesseler, G.M. Cameron, P.A.G. Cormack and N. Bruns, Polym. Chem. (2023) 14, 1456-1468

5. A Facile Route for the Chemical Functionalisation of Polydivinylbenzenes and the Application of Amphoteric Polydivinylbenzene Microspheres to the Simultaneous Solid-Phase Extraction of Acidic and Basic Drugs from Water Samples, F. Borrull, P.A.G. Cormack, A. Corrigan, C. Craig, N. Fontanals, R.M. Marcé, A. Moral, G. Smith, Polym. Chem. (2025) 16, 751-761

Prof Dr Pu Xiao

Shanghai Institute of Ceramics, Chinese Academy of Sciences, China

Topic of Presentation:

Pioneering green photochemical platforms for advanced manufacturing and functional polymers

Professor Pu Xiao is the Group Leader of Green Composite Biomaterials Group and Associate Director of Biomaterials and Tissue Engineering Research Center, Shanghai Institute of Ceramics, Chinese Academy of Sciences. Following the completion of his PhD, he pursued postdoctoral research at the Fachhochschule Nordwestschweiz (Switzerland) and the CNRS (France). He then joined the University of New South Wales as a Lecturer before moving to Australian National University, where he was appointed Senior Lecturer and subsequently promoted to Associate Professor. He recently relocated his group to Chinese Academy of Sciences. His research interests include brain-computer interfaces, green composite biomaterials, photophysical chemistry, photopolymerization technology, 3D printing, and light-induced responses of materials.

PIONEERING GREEN PHOTOCHEMICAL PLATFORMS FOR ADVANCED MANUFACTURING AND FUNCTIONAL POLYMERS

Pu Xiao^a,*

^aChinese Academy of Sciences

Corresponding Author:pu.xiao@uha.fr

Abstract

The development of biomaterials that can promote tissue healing and regeneration is fundamental to the field of regenerative medicine. Our research tackles one of the core challenges in this field by revolutionizing the chemical tools in green biomaterial manufacturing. We address the limitations of conventional photopolymerisation - namely its reliance on toxic and UV light sensitive photoinitiators - by developing a new class of low-toxic visible-light photoinitiators. This innovation paves the way for cytocompatible manufacturing under mild conditions. This presentation will detail our approach, demonstrating how advancing the photochemical “engine” establishes a powerful new paradigm for advanced manufacturing and polymer materials.

Keywords: photopolymerization, photoinitiator, cytocompatible manufacturing

Prof Dr Rizafizah Othaman

Universiti Kebangsaan Malaysia (UKM), Malaysia

Topic of Presentation:

Engineering the future: synergistic frontiers in functional polymers for health, environmental sustainability, and stem engagement

Prof. Ts. ChM. Dr. Rizafizah Othaman is a Professor at Universiti Kebangsaan Malaysia (UKM) and the CEO of ChemSci Sdn Bhd. Currently serving as the Deputy Dean of Industry and Community Partnerships at the Faculty of Science and Technology, she excels in bridging industrial applications with academic rigor. An alumna of the Tokyo Institute of Technology (PhD in Chemical Engineering), she pioneers research in polymeric membranes for energy and environmental sectors, alongside innovative extraction methods for bioactive oligosaccharides. Passionate about societal impact, she actively champions STEM education, transforming complex scientific breakthroughs into sustainable solutions for global challenges.

ENGINEERING THE FUTURE: SYNERGISTIC FRONTIERS IN FUNCTIONAL POLYMERS FOR HEALTH, ENVIRONMENTAL SUSTAINABILITY, AND STEM ENGAGEMENT

Rizafizah Othaman^a,*

^aUniversiti Kebangsaan Malaysia

Corresponding Author:rizafizah@ukm.edu.my

Abstract

Modern polymer science is shifting from passive materials to active, intelligent systems. This keynote lecture examines the convergence of precision-engineered polymers with three pillars: targeted healthcare, intelligent environmental remediation, and the evolution of STEM education. By leveraging stimuli-responsive architectures, we redefine how materials interact with their surroundings to address 21st-century global challenges. In healthcare, we explore dynamic bio-interfaces for complex physiological environments. This section covers the synthesis of polymers exhibiting precise spatial and temporal control. We discuss breakthroughs in adaptive drug delivery and functional scaffolds that respond to endogenous stimuli such as pH or enzyme concentration, to improve therapeutic outcomes through precise, biocompatible patient care. Environmentally, we focus on smart materials for active remediation, moving beyond passive biodegradation to intelligent polymers with dynamic environmental response. This includes high-affinity, stimuli-responsive adsorbents for the selective capture of aquatic and atmospheric pollutants, alongside self-healing coatings that extend material lifespans and drastically reduce systemic waste. By integrating responsive functionality at the molecular level, we shift the environmental paradigm from static waste management to proactive resource conservation and active decontamination, ensuring that the lifecycle of high-performance polymers is inherently sustainable. Finally, we advance our commitment to STEM education. The increasing complexity of functional materials requires new pedagogical frameworks to translate cutting-edge research into accessible, inquiry-based learning. It highlights innovative bridges between laboratory breakthroughs and the classroom, utilizing interactive digital platforms, virtual material science modules, and global citizen-science initiatives. By empowering the next generation to engage directly with smart material concepts, we foster a scientifically literate populace capable of advocating for and implementing sustainable material solutions. This lecture synthesizes these pillars to illustrate how interdisciplinary collaboration addresses global issues, ensuring the future of polymers remains both functionally advanced and deeply integrated into our societal ecosystems.

Keywords: Functional Polymers, Stimuli-Responsive Materials, Biomedical Applications, Environmental Remediation, STEM Education

Assoc Prof Dr Siti Fairus Mohd Yusoff

Universiti Kebangsaan Malaysia (UKM), Malaysia

Topic of Presentation:

Designing natural rubber–based polymer–inorganic hybrid materials for environmental remediation

Assoc. Prof. ChM. Dr. Siti Fairus Mohd Yusoff of Universiti Kebangsaan Malaysia is internationally engaged in the field of polymer science, with research contributions spanning functional polymer materials, hybrid nanocomposites, and sustainable technologies for environmental remediation. Her work, particularly on natural rubber-based hydrogels and photocatalytic systems, has advanced innovative solutions for water treatment and functional material design. She has authored numerous indexed publications, books, and book chapters, and holds patents in advanced polymeric materials. A recipient of several research and innovation awards, she is active in fostering international scientific collaboration and advancing sustainability-driven materials research.

DESIGNING NATURAL RUBBER–BASED POLYMER–INORGANIC HYBRID MATERIALS FOR ENVIRONMENTAL REMEDIATION

Siti Fairus Mohd Yusoff^a,*, Mhonishya Krishnamoorthy^a

^aUniversiti Kebangsaan Malaysia

*Corresponding Author:sitifairus@ukm.edu.my

Abstract

Sustainable functional materials are increasingly important for solving environmental challenges, especially when catalytic activity, flexibility, and long-term stability are needed at the same time. Among various material systems, natural rubber-based polymer–inorganic hybrids stand out because they combine renewable, flexible polymer properties with the functionality of inorganic components. This research focuses on developing sustainable hybrid materials using natural rubber as the main matrix, integrated with metal oxides and conducting polymers. Natural rubber is highly attractive because it is renewable, widely available in Malaysia and Southeast Asia, and can be chemically modified to introduce functional groups and form three-dimensional hydrogel networks. These features allow it to act not only as a supporting matrix but also as an active component that enhances pollutant adsorption, structural flexibility, and stabilization of catalytic particles. A key aspect of this work is the design of strong interactions between the polymer and inorganic phases. These interactions influence material morphology, dispersion, stability, and overall performance. By carefully controlling composition and structure, the developed materials show improved catalytic efficiency, better charge transport, porous structures for accessibility, and enhanced reusability. Examples include BiFeO₃-based nanocomposite hydrogels and other natural rubber hybrid systems designed for environmental applications such as pollutant degradation and water treatment. Advanced characterization techniques provide insights into the distribution of active components and the role of polymer–inorganic interactions in determining performance. Overall, this study demonstrates that combining soft natural rubber with functional inorganic materials can produce multifunctional systems with superior properties compared to single-component materials. It highlights the strong potential of natural rubber-based hybrids as sustainable platforms for environmental and catalytic applications, while also improving understanding of structure–property relationships in complex hybrid systems.

Keywords:rubber-based hydrogel, BiFeO3, photocatalysis, adsorption, water treatment

References

1. Ahmad, N. H.; Mohamed, M. A.; Yusoff, S. F. M. J. Sol-Gel Sci. Technol. 2020, 94, 322–334.

2. Mohd Noor, N. F.; Yusoff, S. F. M. Polym. Test. 2020, 81, 106200.

3. . Krishnamoorthy, M.; Ahmad, N. H.; Amran, H. N.; Mohamed, M. A.; Mohd Kaus, N. H.; Yusoff, S. F. M. Int. J. Biol. Macromol. 2021, 182, 1495–1506.

Prof Dr Suwabun Chirachanchai

Chulalongkorn University, Thailand

Topic of Presentation:

Functional vitrimeric bio-based elastomers via dynamic covalent bonds: a potential utilization of rubber seeds

Prof. Suwabun Chirachanchai is a Professor at The Petroleum and Petrochemical College (PPC), Chulalongkorn University, Bangkok, Thailand, and has previously served as dean of the college. He earned his B.Sc., M.Sc., and Ph.D. degrees in Applied Fine Chemistry and Functional Polymer from Osaka University, Japan. His research encompasses polymer modification, functional and biodegradable polymers, biopolymers including chitin‑chitosan, nanomaterials, and advanced polymer composites. He has published over 120 peer-reviewed international journal articles, contributed to international scientific committees, and received multiple national and international awards for his work. His contributions continue to advance polymer science globally

FUNCTIONAL VITRIMERIC BIO-BASED ELASTOMERS VIA DYNAMIC COVALENT BONDS: A POTENTIAL UTILIZATION OF RUBBER SEEDS

Suwabun Chirachanchai^a,* ,Patakorn Pilasen^a ,Ratthapit Wuttisarn^a ,Shinji Kanehashi^b

^aChulalongkorn University,

^bTokyo University of Agriculture and Technology

Corresponding Author:suwabun.c@chula.ac.th

Abstract

Rubber seeds are typically left in the soil as agricultural waste, however, their oil (RSO) contains saturated and unsaturated fatty acids (FAs), such as palmitic acid, stearic acid, oleic acid (OA), linoleic acid (LA), and linolenic acid, making it a promising sustainable material. To date, studies on exploring RSO as a sustainable resource remain limited. From our perspective, the combination of FAs with dynamic covalent bonds (DC) could potentially yield vitrimers¹ with tailorable properties. From this viewpoint, the present work investigates a model system combining FAs with DC bonds to prepare bio-based vitrimeric elastomers using LA and OA as building blocks. Two types of DC networks are successfully developed: acetal-based networks (Scheme I (A)) and vinylogous urethane networks (Scheme I (B)). The presentation highlights the unique material properties, including stretchability, adhesive performance, reprocessability, and self-healing capability. The presentation will also extend to other related materials using FAs which can be derived from RSO.

Keywords: Vitrimer, Elastomers, Dynamic covalent bonds, Rubber seed oil, Covalent adaptable networks

References

1. Damien M.; Capelot M.; Tournilhac F.; Leibler L. Science, 2011, 334, 965.

Assoc Prof Dr Winita Punyodom

Chiang Mai University, Thailand

Topic of Presentation:

Thermally responsive plgc nanoparticles: synergizing rubbery-state matrices with poloxamer for intracellular delivery

Associate Professor Dr. Winita Punyodom is a Vice President of Chiang Mai University. She earned her doctorate in philosophy in polymer physics from the University of Leeds, UK. Her research areas of interest include the development of novel catalysts, specialty polymers, and bioplastic innovation for the target industry, as well as their potential use in bioplastics and biomedical applications. She has published more than 150 research papers, obtained 5 patents, and received several grants from the government and industry worth more than 200 million baht. As one of her team CMU’s technology in materials design, “Bioplastic Production Laboratory for Biomedical Applications” accredited ISO13485 (Medical devices-Quality management systems-Requirements for regulatory purposes) offers customized products for use in various applications, in particular, medical applications. In 2023, she received the Materials Research Society of Thailand's award for the Best Material Researcher in Thailand.

THERMALLY RESPONSIVE PLGC NANOPARTICLES: SYNERGIZING RUBBERY-STATE MATRICES WITH POLOXAMER FOR INTRACELLULAR DELIVERY

Winita Punyodom^a,* ,Nuttawut Khammata^a ,Wanwanut Chueasupcharoen^a ,Jutamas Kongsuk^a ,Donraporn Daranarong^a ,Kiattikhun Manokruang^a ,Chawan Manaspon^b ,Kittisak Yarungsee^c ,Matthew J. Derry^c ,Brian J. Tighe^c ,Paul D. Topham^c

^aDepartment of Chemistry, Faculty of Science, Chiang Mai University,

^bBiomedical Engineering Institute, Chiang Mai University,

^cAston Institute for Membrane Excellence, Aston University

Corresponding Author:winita.punyodom@cmu.ac.th

Abstract

The therapeutic efficacy of polymeric nanocarriers is frequently limited by the structural rigidity of conventional polymers and poor interactions at the nano-bio interface. To address these fundamental challenges, we engineered thermally responsive poly(lactide-co-glycolide-co-caprolactone) (PLGC) nanoparticles designed to transition into a compliant, rubbery state at physiological body temperature. This elastomeric core provides enhanced structural flexibility to facilitate sustained drug release. Furthermore, to govern the dynamic nano-bio interface, the surfaces of these nanocarriers were functionalized using distinct amphiphilic triblock copolymers (Poloxamers). Our comprehensive evaluations revealed that the specific macromolecular architecture of the surfactant corona plays a pivotal role in determining the biological fate of the nanoparticles. While all formulated nanocarriers exhibited excellent colloidal stability and structural resilience in complex biological environments, their cellular internalization efficiencies varied drastically. In vitro assessments demonstrated that nanocarriers stabilized with a more hydrophobic Poloxamer achieved a profoundly higher intracellular accumulation compared to those stabilized with a more hydrophilic counterpart, while maintaining a high degree of cytocompatibility. This significant enhancement in cellular uptake is attributed to the surfactant's ability to favorably interact with cellular membranes and modulate efflux mechanisms. Ultimately, this study establishes a highly effective design paradigm, demonstrating that the synergistic combination of a flexible, rubbery-state polymer matrix with an optimized surface corona can dramatically maximize the potential of intracellular drug delivery systems.

Keywords: PLGC nanoparticles, Rubbery-state polymer, Poloxamer, Cellular internalization, Drug delivery

References

1. Bodratti, A. M.; Alexandridis, P. J. Funct. Biomater. 2018, 9, 11
2. Batrakova, E. V.; Kabanov, A. V. J. Control. Release. 2008, 130, 98-106

Prof Dr Zhenzhong Yang

Tsinghua University, China

Topic of Presentation:

Janus nanostructures of polymer single-chains

Zhenzhong Yang is professor of polymer science and materials at Tsinghua University. After studies at Tsinghua University, Jilin University, Institute of Chemistry of Chinese Academy of Sciences (ICCAS), he worked as postdoctoral fellow during 1997-1998 at BASF (Germany). He worked in ICCAS during 1998-2018. He ever served as director of Polymer Physics and Chemistry Laboratory (ICCAS), secretary general of Chinese Chemical Society, deputy director of ICCAS. He was awarded National Science Funding for Distinguished Young Scholar (2003), and National Natural Science Award of China (2013, Second Class). His research interests cover composite spheres and capsules, Janus composites and single-chain derived nanostructures (nanoparticles and rings).

JANUS NANOSTRUCTURES OF POLYMER SINGLE-CHAINS

Zhenzhong Yanga,*

aTsinghua University

Corresponding Author:yangzhenzhong@mail.tsinghua.edu.cn

Abstract

Polymer single-chain nanostructures of nanoparticles (SCNPs) and nanorings are analogous to biomacromolecular species of proteins and nucleic acids.1 In engineering, polymer SCNPs are promising in high performance composites and intracellular therapy.2 What’s more, Janus nanostructures of distinct compartments should deserve more attention owing to hybridized performances of the constituents. Focusing on dilemma of conventional synthesis of SCNPs and nanorings in dilute solutions, we proposed electrostatics-mediated intramolecular crosslinking of polymer single-chains toward SCNPs in concentrated solutions.3 Within the dynamic SCNP intermediates, end-to-tail closure becomes more effective to achieve highly pure polymer rings in concentrated solutions.4 The electrostatics-mediated synthesis is valid to large-scale synthesize polymer nanorods from the parent bottlebrushes via intramolecular crosslinking.5 Under the inherent electrostatics-mediation, exclusive intramolecular cyclization is achieved via living ionic polymerization of multi-valence monomers toward single-chain nanoparticles and the Janus derivative. The electrostatics-mediation is crucial to large-scale synthesize the nanostructures in concentrated solutions.

This work is supported by NSFC (No. 52293472 and 51833005).

Keywords: single-chain nanostructure, nanoring, nanorod, electrostatics-mediation, large-scale synthesis

References

1. Prog. Polym. Sci. 2022, 133, 101593.

2. Phys. Rev. Lett. 2025, 135, 118101.

3. CCS Chem. 2019, 1, 407.

4. Macromolecules 2025, 58, 4131.

5. J. Am. Chem. Soc. 2025, 147, 6857.